Everything at Canyon Ranch is done on a big, unique scale. To wit: In Lenox, a former U.S. surgeon general oversees medical care. Healing from the inside out is a major reason to book time here with doctors, nurses, physical therapists, acupuncturists, nutritionists, and personal trainers. They'll all help you manage the chronic illnesses of our fast-paced modern life—diabetes, heart...

"Life in balance" is the promise and tagline of this desert spa resort, which ministers to overstressed and enervated guests with a variety of all-encompassing wellness programs and connected travel experiences. The location showcases two very dramatic terrain features: the Sonoran Desert and the Catalina Mountains, with indoor-outdoor architecture (including outdoor treatment "rooms" in the...

Just north of Miami, a stretch of white sand anchors this oceanfront property that's home to the lavish ESPA spa and Acqualina resort, topped by 51 stories of luxury condos. That combo means you can stay for a day, a week, or a lifetime. A limited number of international five-star properties boast ESPA spas, and this is one of just three in the U.S. It combines sophisticated classic and modern...

Historic grace, castle-like architecture, and a ghostly legend or two set this Canadian classic apart from other destination spas in the land—as well some of the other more hyperkinetic all-inclusives on this list. Rest and relaxation are the first steps to transformation. Other key components include specialty treatments, wellness classes, garden-fresh gourmet cuisine, and endless...