Thankyou those are some great ideas!

Yes, that's a long drive, so you'll want to break things up! Not sure how long you've got (nor your timing), but here are a few quick ideas: jazz and BBQ in Kansas City; baseball and the Gateway Arch in St. Louis; trip to the Jim Beam plant near Lexington, KY; hiking, biking, and rafting (in-season) in the New River Gorge, WV; pit stop at a historic resort like The Greenbrier (White Sulphur Springs, WV) or The Homestead (Hot Springs, VA); hiking in Mount Rogers NRA or Grayson State Park, VA, or drive a stretch of the Blue Ridge Parkway; bike the Virginia Creeper Trail from Abingdon, VA. Let me know if you need more ideas! Enjoy your trip!