Route 66, popularly called the "Mother Road," originally started out from Chicago, passing through St. Louis on its passage west to L.A. Although now decommissioned as an official "highway," you can still travel the byways of this historic route, one of the country's pre-eminent National Scenic Byways. Learn more about Route 66 history and get travel-planning advice here: http://www.byways.org/explore/byways/2489/.