Cathy, take a look at Jamie Jensen's Road Trip USA guide (guidebook, but also has information available here: http://www.roadtripusa.com/routes/loneliestroad/loneliestroad.html). He plots some highlights along US-50, the "loneliest road," that covers the drive through Missouri (get outdoors in the Ozarks!), Kansas, and through southern Colorado. The link above includes specific sights and attractions through each of the states. Hope this helps!